MILPRAZONE anthelmintic for adult cats weighing more than 2 kg pack. 2 tablets KRKA

Composition of Milprazone, release forms and storage conditions

Milprazone is a combination drug with an extensive antiparasitic spectrum, produced by the Slovenian company KRKA (KRKA ddNovo Mesto LLC).

Milprazone is available in the form of tablets of two dosages for pets of different weights, so they differ in the dose of active ingredients and are labeled in different colors: for kittens and small cats weighing up to 2 kg, they are brown-yellow, and for pets whose weight exceeds 2 kg, they are brown-red . Both dosages of the product have a meat flavor to make feeding it to pets easier. The Milprazone tablet has an oval shape, both of its surfaces are convex, and one of them contains a line that facilitates separation for dosing accuracy. To prevent premature release of active ingredients, the tablets are coated with a thin film. Milprazone is placed in blisters, each blister can contain 2 or 4 tablets; the product is provided with instructions for use and packaged in a cardboard pack, which may contain 2, 4 or 48 tablets.

For pets under 2 kg, Milprazone tablets are yellow-brown in color.

Table: composition of Milprazone for cats

Milprazone is stored for 3 years under certain conditions:

• sealed original pack;
• away from human food and pet food;
• protection from dampness and sun exposure;
• inaccessible to children;
• temperature range 5–25o C.

If after using Milprazone there is half a tablet left, it is removed back and used next time, but it cannot be stored for more than six months.

For cats weighing more than 2 kg, Milprasone tablets are red-brown

Price

The cost of Milprazone tablets depends on their quantity in the package and what age they are intended for: for kittens and cats up to 2 kg - from 250 rubles. for 2 tablets; tablets for cats over 2 kg - from 400 rubles. for 2 tablets.

How to Give Tablets to Cats?

Also read: The drug Helmintal - use and dosage.

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Indications for use of Milprazone

Milprasone treats and prevents diseases caused by parasitism of the most common types of worms: roundworms and tapeworms. The drug is active against both adult forms (imago) and their larvae.

Milprazone is active against pathogens:

• dipylidia;
• echinococcosis;
• taeniasis;
• hookworm;
• toxocariasis;
• dirofilariasis.

Dirofilariasis in cats

Unfortunately, in the last decade, veterinarians have been diagnosing dirofilariasis more and more often, and it has lost its status as a rare invasion. This is due both to improved diagnosis and to the expansion of the geographical area of ​​the disease, which is naturally focal. Dirofilariasis is most common in the Russian Federation in the Rostov, Astrakhan regions, Kuban and Crimea. In smaller numbers, but regularly, cases of dirofilariasis are recorded in Moscow, central Russia, the Urals, the Far East and Siberia.

The causative agent of dirofilariasis is Dirofilaria immitis, a roundworm that lives in the right side of the heart in cats and reaches a length of 21 cm, and is the most dangerous parasite. The cat becomes its definitive host; infection occurs through mosquito bites that transmit microfilariae, the larval form of dirofilariasis. Cats get sick about 10 times less often than dogs, this is associated with their better resistance, but the consequences of dirofilariasis in cats are much more severe than in dogs, and the treatment and diagnosis of this disease for them are much less developed.

Massive damage to the heart chambers by heartworms

Symptoms of dirofilariasis in cats:

• apathy;
• loss of appetite and weight;
• exercise intolerance;
• cough;
• dyspnea;
• heart rhythm disturbances, heart murmurs are heard;
• increase in heart size;
• swelling of the extremities, accumulation of fluid in the pleural and abdominal cavities with the development of heart failure;
• possible sudden death as a result of pulmonary embolism by a dead parasite.

The only reliable method of ridding a cat of parasites is their surgical removal from the chambers of the heart; the risk is high. According to foreign researchers, the survival rate of cats after diagnosis is 1.5–4 years, with a worse prognosis if infected at a young age.

A reliable method of preventing serious illness is taking drugs that are active against microfilariae, one of which is Milprazone. Prevention in cats is necessary in those regions where prevention is carried out in dogs. According to foreign authors, up to 30% of infected cats were exclusively kept in apartments, and this did not protect them from infection.

Prevention of dirofilariasis begins at 8 months, 1 month before the mosquito flight season, throughout the entire flight season, and 1 month after it. The year-round presence of mosquitoes requires year-round prevention.

Video: dirofilariasis in pets

How does Milprazone work?

Milprazone has a combined composition, and its action is realized through the combined effects of the active ingredients - milbemycin oxime and praziquantel.

Milbemycin is active against roundworms (nematodes), kills both mature individuals that parasitize in the lumen of the digestive system, and larvae that are carried through the bloodstream through the internal organs, causing tissue damage. It also has a detrimental effect on the larval form of the dirofilariasis pathogen, preventing its development. Milbemycin increases the content of chloride ions in the cells of nerve fibers and muscles of parasites, which causes paralysis and subsequent death. After taking the tablet, the highest concentration of milbemycin in the serum is recorded after 2 hours; the substance is excreted unchanged, losing half of its therapeutic activity within 13 hours.

Praziquantel destroys roundworms and tapeworms (cestodes), increasing the content of intracellular calcium. This leads to paralysis of the muscles of the worms, and also damages the tegument - the outer shell of the parasite, which protects it from the effects of the cat’s digestive enzymes. Praziquantel reaches its maximum level in the blood an hour after taking the tablet and is excreted by the kidneys in the form of inactive metabolic products with the loss of half of its activity after 3 hours.

Milprazone tablets are defined as a moderately hazardous chemical compound, and if the dosage regimen is followed, they do not show any effect:

• embryotoxic - do not cause damage to the embryo with subsequent miscarriage;
• teratogenic - do not cause malformations in the fetus;
• sensitizing - do not cause allergic restructuring of the immune system with the subsequent formation of hypersensitivity reactions.

Cats tolerate Milprazone well, but it is harmful to bees and aquatic life.

Effect of the drug

Reviews of Milprazone for cats indicate the amazing effectiveness of the drug. It is explained by the presence of two active ingredients in the composition. It is they that, when entering the animal’s blood, infect the nervous system and tissues of the parasites. In addition, the development of larvae that were laid by helminths for reproduction stops. All individuals, regardless of life cycle and size, die. The remains of their vital activity are excreted from the cat’s body along with feces.

The drug is a potent drug. Therefore, it must be given to the animal with extreme caution so as not to harm the pet’s health. You should always carefully read the instructions for use of Milprazone for cats. Reviews from pet owners indicate that the tablet should be given strictly based on the weight of the pet.

Features of using Milprazone in cats

For effective treatment with Milprazone, it is important to follow its instructions.

Selection of dosage

The dose is selected based on the weight of the pet. To achieve the effect, 2 mg of milbemycin and 5 mg of praziquantel are required for each kg of the pet’s weight.

Table: selection of the dose of Milprazone for a cat

Reception scheme

For treatment, Milprazone is prescribed based on the presence of worm infestation; for prevention, it is prescribed once per quarter. If the next preventative dose is missed, the drug should be taken as quickly as possible without changing the dosage. Milprazone is also used 10–14 days before vaccination and mating. This period is necessary for the complete recovery of the body from intoxication caused by dead parasites, which is especially pronounced with irregular use of anthelmintics. Milprazone protects against heartworm infection only for 1 month, and if the pet lives in a region where heartworm disease is endemic, it is necessary to use a different drug every month, containing only milbemycin oxime or another ingredient with activity against heartworms. The manufacturer does not recommend monthly use of Milprazone for this purpose.

Milprasone is offered to the pet along with a handful of food or force-fed, placed on the root of the tongue. Milprasone does not require prior fasting or laxative use.

Use during pregnancy and in kittens

Milprazone is approved for use during pregnancy and lactation under medical supervision. It is not prescribed to kittens under 6 weeks of age, or those weighing less than 0.5 kg. When prescribing the drug to kittens, special attention is required, since side effects develop in them more often than in adult pets.

How to give a pill to a cat

There are several ways to feed the tablet to your cat:

• Voluntary feeding along with food - a hungry pet is offered a tablet along with a minimum amount of food so that everything is guaranteed to be eaten.
• Voluntary feeding along with a treat - the tablet is offered to the cat, having previously hidden it in a treat, for example, a ball of cheese or minced meat.
• Force feeding:
  Grasp the cat's head from above with your left hand and press with your thumb and forefinger on the base of the cat's jaw on both sides, achieving an opening of the mouth.
• With your right hand, place the product on the root of the tongue.
• Close the cat's mouth and hold it closed.
• Release the cat's head while continuing to keep the jaws closed.
• Gently stroke the cat's throat, provoking a reflex swallowing movement.
• If the cat is strong and evasive, you can grab it by the skin on the back of the neck and lift it up. This will not cause her pain, but will reflexively ease the tension of the chewing muscles, and the mouth will open slightly.
• You can use a piller (tablet dispenser), which is a plastic tube equipped with a piston for pushing out the tablet. Using a peeler does not require wide opening of the cat's mouth, saves energy and time, and also protects fingers from the pet's teeth. The piller can be made independently from a syringe, the diameter of which coincides with the size of the tablet, by cutting off its distal part.

Video: how to give a pill to a cat

What to do in case of overdose

An overdose occurs when the dosage regimen is violated, as well as when a cat spontaneously eats a freely available drug. Her symptoms:

• general weakness;
• impaired coordination of movements;
• muscle tremors;
• vomit;
• diarrhea.

If the symptoms are moderate, the cat should be monitored, since in most cases the condition normalizes on its own within 24 hours. If the health disorder is significant, and symptoms persist for more than a day, the pet must be taken to a veterinarian for symptomatic therapy:

• To reduce the concentration of the drug in the blood, infusion therapy (droppers) with solutions of: Ringer's is carried out;
• saline solution.

If symptoms of Miprazole overdose persist for more than a day, you should consult a doctor.

Safety when using Milprazone

The manufacturer recommends taking the following safety measures:

• Persons allergic to the components of Milprazone should not have direct contact with it.
• If the drug accidentally gets on the skin and mucous membranes, it must be quickly washed off using soap and running water.
• When working with Milprazone, do not eat, drink or smoke, which avoids accidental ingestion of the drug.
• After finishing working with Milprazone, be sure to wash your hands using soap.
• If a person accidentally swallows Milprazone, or if an allergy to the drug develops, it is necessary to immediately consult a doctor, taking with you the instructions for the drug or its packaging to facilitate identification of the drug.

How to store a veterinary drug

Milprazone should be stored out of the reach of children and away from food. The optimal storage temperature is 5–25 °C.

The shelf life of the medicinal product, subject to storage conditions in the manufacturer's closed packaging, is 3 years from the date of production. The opened half of the tablet can be stored for six months ( for kittens weighing less than 2 kg - no more than three months). After the expiration date, packaging and unusable medications must be disposed of with household waste.

Drug-drug interactions

The manufacturer indicates that Milprazone is compatible with selamectin (the active substance of Stronghold); There are no data on combined use with other macrocyclic lactones. Macrocyclic lactones as active ingredients are included in many antiparasitic drugs, including those used regularly against external parasites, for example, Advocate drops, so compatibility between drugs must be taken into account.

Table: comparative review of Milprazone tablets for cats

Photo gallery: Milprazone analogues

Milbemax is a complete analogue of Milprazone, used quarterly

Helmimax has a similar spectrum of action, and can also be used for monthly prevention of dirofilariasis, since it contains another active ingredient = moxidectin, a more modern

Stronghold drops on the withers are destructive to external parasites, fleas and ticks, as well as roundworms and their larvae, but do not affect tapeworms, suitable for monthly use

Advocate drops have a spectrum of action similar to Stronghold and are used monthly

Contraindications and side effects

Milprazone is not recommended for use in cats with individual intolerance. Among the contraindications in the instructions for use are listed:

• kidney disease;
• impaired liver function;
• infectious diseases;
• exhaustion;
• age up to 6 weeks. Milprazone should not be used for kittens weighing less than 500 g.

It is possible to treat helminthic infestation in pregnant cats or lactating females only under the supervision of a veterinarian.

Side effects may include diarrhea, vomiting, apathy, tremor, and ataxia. Most often, such symptoms are characteristic of kittens. Otherwise, if the instructions for use are followed, cats have good tolerance to the anthelmintic, which is confirmed by reviews.

Owner reviews

Of course, they promised me that the cat would happily eat this pill.
No matter how it is. I mixed it with dry food and stuffed it into sausage, just like in the movie. But the tablet still remained in the bowl. In the end I had to mix it with wet food. After that, the tablet went where it was supposed to go. Antanel
https://otzovik.com/review_7017685.html

In general, I am a little disappointed with these tablets, because one of the cats still had to force it into his mouth, and we specifically spent a considerable amount so that this would not have to be done.
Although the tablets themselves are convenient for deceiving a cat’s vigilance. Or maybe my Marquis is just too cunning. So I still recommend these tablets for purchase. Leno4ka-Peno4ka
https://otzovik.com/review_3616333.htm

Milprazone is a combined broad-spectrum anthelmintic drug, an analogue of Milbemax. Milprazone destroys round and tapeworms, as well as their larvae. A significant advantage of Milprazone is the ability to prevent the development of dirofilariasis, but the manufacturer recommends its quarterly use, so there is a need to use other means in endemic areas during insect flight in those months when Milprazone is not used.