When to inject Fosprenil for cats - antiviral: instructions and dosage

For what diseases is Fosprenil used?

This drug has pronounced immunomodulatory and therapeutic properties and has a wide spectrum of action.

Fosprenil

Its main goal:

• increasing the body's resistance to viral infections;
• prevention of epidemics in case of mass infection of animals.

Important! The action of the pharmacological composition is targeted and can be used simultaneously with many medications.

Advantages and disadvantages of the drug

The advantages of Fosprenil include several factors:

• accessibility (the medicine can be bought at almost any veterinary pharmacy);
• low price (from 140 rubles per 10 ml bottle);
• no contraindications (except allergies);
• low risk of side effects;
• Fosprenil does not contain toxic substances.

The disadvantage of this immunomodulator is its unproven effectiveness (or its low degree). There is currently no scientific evidence that the drug actually affects the course of treatment, for example, for viral infections. All conclusions about the drug are made only on the basis of the experience and practice of those people who used it. In addition, Fosprenil is most often used in combination with other medications, so even successful treatment may be due to them.

After talking with the seller from the nearest veterinary pharmacy, I came to the conclusion that Fosprenil may also have counterfeits. Of course, the pharmacist didn't tell me how to identify them. Only one thing is clear: you need to carefully study the packaging, and it is better to buy 10 ml bottles immediately in a box, and not individually. By the way, if the veterinary pharmacy did not offer you several different packaging options at once, then there is a great chance of buying real Fosprenil.

One of the disadvantages of Fosprenil is the likelihood of “running into” a fake

How to use Fosprenil in different animals, dosage

The pharmacological drug is administered orally, intramuscularly, intravenously.

Treatment by spraying in areas where animals are kept, external application and addition to feed is allowed:

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How to use Fosprenil:

1. During vaccination, to avoid complications, 0.05 ml/kg is administered intramuscularly along with the medicine. Injections are performed with different syringes.
2. Large daily dosage is performed:

• in several stages;
• 1/2 intravenously;
• to different points.

1. In non-specific cases, the method and dosage rates are specified in the instructions for the drug.
2. In particularly difficult cases of illness, the course can be repeated. The decision in this situation is made by the veterinarian.

The working solution for aerosol spraying is prepared in the proportion of 20 ml of Fosprenil per 1 liter of water with the addition of 10% glycerin.

The treated area is calculated from the proportion of 0.4 ml per 1 cubic meter. Spraying is carried out for ¼ hour.

Fosprenil for cats: reviews

In most cases, this solution has positive reviews. Pet breeders have noted a rapid improvement in the cat’s condition even with severe illnesses (for example, with the herpes virus, improvement occurs approximately on the third day of complex therapy).

In addition, buyers note that most pets easily tolerate treatment with the drug, since the injections are practically painless, and the possibility of oral administration makes the medication extremely convenient for treating kittens and severely weakened animals.

Another advantage noted by owners of domestic cats is the attractive cost of Fosprenil. A simple injection solution is much cheaper than expensive antiviral drugs in tablets.

Negative reviews are extremely rare; they mainly contain information about side effects in the form of lethargy and fever, but these phenomena are mainly associated with incorrect dosage calculations.

Side effects

Important!
Do not skip drug administration, as this leads to a decrease in effectiveness. According to GOST 12.1.007.76, the pharmacological agent belongs to substances of hazard class 4.

Administration at recommended dosage:

• does not produce locally irritating effects;
• does not have allergenic effects.

A slight increase in body temperature, lethargy, and a short-term loss of appetite are allowed. These deviations are considered normal.

Information on the cost of veterinary medicine and its analogues

Fosprenil is available in veterinary pharmacies without a prescription. On average, the cost of packaging 5 bottles of them, with a capacity of 10 milliliters each, is 850 rubles.

You can buy Fosprenil at any veterinary pharmacy without a doctor's prescription.

Among Fosprenil analogues one can see many veterinary drugs with immunomodulating properties. We are talking about Gamavit, Maksidin, Forvet and others.

Table: list of drugs analogues of Fosprenil

Contraindications for use

In case of individual intolerance to certain components in animals, it is recommended to use the solution with caution.

1. The therapeutic effect may be reduced:

• when using Fosprenil with anti-inflammatory drugs based on hormones produced by the adrenal glands;
• if the composition was diluted with saline solution.

1. Meat and dairy products obtained from treated animals can be used without restrictions.

Instructions for use of Fosprenil

The sterile solution is intended for injection or oral use. The injection is given in any of three ways: intramuscularly, intravenously, subcutaneously. The earlier treatment is started, the greater the chances of getting a positive result and achieving recovery for the cat. Veterinarians recommend starting to administer Fosprenil in the prodromal period, that is, in the interval between the incubation period and the immediate manifestation of symptoms of the disease.

During treatment with this drug, it is advisable to follow the injection schedule. If one is missed, the next dose should be administered as soon as possible. In this case, the amount of the drug does not exceed. The solution is also used to wash the eyes and nasal cavity of a pet during viral infections.

In order not to reduce the therapeutic effect, Fosprenil is not combined with steroid medications

How to inject medicine into a cat

An intramuscular injection of Fosprenil is given into large skeletal muscles. The first place is located in the upper thigh. The needle is inserted from the tail. The second place is located in the upper third of the shoulder. The needle is inserted from behind the abdomen. The withers or the area between the shoulder blades is suitable for subcutaneous injection. The skin is lifted with your fingers and a needle is inserted under the fold.

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Intravenous administration of the drug requires skill. If it is absent, you should not experiment at home; it is recommended to go to the clinic. The intravenous injection technique involves several sequential manipulations:

1. The paw is tied with a tourniquet.
2. A needle without a syringe is inserted into the distended vein.
3. Connect a syringe with medicine to the needle.
4. Allow blood to enter the cavity of the syringe.
5. Remove the applied tourniquet.
6. The drug is slowly injected into a vein.

Fosprenil injection is not recommended to be diluted with saline solutions

Composition and action of Fosprenil

The substance is a transparent solution that may have a light yellow tint or be completely colorless.

Includes:

The drug begins to act when the body accumulates the required amount of the substance:

• after administration it enters the circulatory system;
• accumulates in the liver, spleen and reproductive organs;
• The maximum concentration occurs within 0.5-3 hours and lasts 10-16 hours.

It is excreted from the body naturally through feces.

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Description of the drug Fosprenil

Phosprenyl is a veterinary drug used as an immunomodulator with antiviral properties. The international name of Fosprenil is disodium salt of polyprenols phosphate. The developer and manufacturer of this immunomodulating agent is Moscow.

Fosprenil is produced by a domestic organization

Historical background: in the 80s of the 20th century, scientists from several pharmaceutical and biological fields united and created an enterprise to promote their progressive developments. In 1992 they registered (closed joint stock company). The products of the domestic manufacturer began to be in demand from the first days, so a few years later special laboratories were created specializing in the processing of woody greenery.

In 1994, scientists managed to obtain the required solution, which became the basis for many immunomodulators. Fosprenil, which became the first practical result, was studied clinically on dozens of farms and tens of thousands of birds and large animals. Now Micro-Plus is considered one of the most successful Russian business entities in this area.

Composition of the drug

The active ingredient of the immunomodulator is disodium salt of polyprenols phosphate (1 ml of Fosprenil contains 4 mg). And excipients:

• glycerin - 0.03 ml;
• ethanol - 0.029 ml;
• Tween-80 (food additive E433 - emulsifier of the group of surfactants);
• water for injection - up to 1 ml.

Any packaging of Fosprenil indicates the international nonproprietary name - disodium salt of polyprenol phosphate

Release form

Fosprenil is a clear, sterile solution for injection. But it may be a little cloudy (colorless or yellowish in color). The solution is packaged in transparent glass bottles of 10 and 50 ml. Each bottle is sealed with a rubber cap, and it is sealed with an aluminum cap. This allows you to maintain the sterility of the drug.

The bottles are packed in white cardboard boxes. Inside the box there are instructions for use with a detailed description of indications and contraindications. The manufacturer, volume, active ingredient, batch and expiration date are indicated on the box, as well as on the bottle. Any Fosprenil label must have the manufacturer’s logo. Some boxes have a holographic sticker.

I asked our veterinary pharmacy for both volumes of Fosprenil. Large bottles were sealed with silver caps, and small bottles with green caps. However, the pharmacist explained to me that small bottles can also have silver caps (it all depends on the batch of goods and the date of manufacture).

10 ml bottles can have either silver or green caps

Storage conditions

The instructions for use of Fosprenil indicate storage conditions:

• the drug must be stored in the original box;
• the storage location should be away from food and animal feed;
• Fosprenil should be stored in a dry place protected from the sun;
• children, animals and unauthorized persons should not have access to the first aid kit;
• optimal storage temperature is from 4 °C to 25 °C;
• The shelf life of the drug is 2 years from the date of manufacture;
• After the expiration date, the drug cannot be used;
• Damaged or expired products must be disposed of in accordance with general rules.

Pharmacological properties

It affects paramyxo-, orthomyxo-, toga-, herpes-, corona- and some other types of viruses.

1. The best effect is achieved by etiotropic therapy in the initial period, so use should be started when the first symptoms appear:

• viral epidemiology requires the use of pathogenetic therapy;
• in complicated forms, a dosage doubled is allowed;
• the main course is stopped on the 2-3rd day of absence of symptoms of the disease.

1. During the therapeutic effect, the process of activating metabolism at the cellular level occurs, BASK and phagocytosis are stimulated, and the immune response to the vaccine is enhanced.

In prosperous farms, only disinfection with Fosprenil is necessary to increase the profitability of fattening young animals.

How it works

An antiviral drug containing polyprenolic phosphates has a whole range of useful properties. They determine the therapeutic effect of the drug. The immunomodulatory effect of Fosprenil in the body consists of the following processes:

• Strengthening the phagocytic function of leukocytes.
• Increased bactericidal activity of whey proteins.
• Stimulation of the synthesis of own antibodies.
• Activation of metabolic processes inside cells.
• Decreased activity of viral particles.
• Restoration of cellular structures.
• Increased antioxidant protection.

As a result of complex biochemical changes, the cat’s body reacts more adequately to the introduction of viruses into cells and more actively fights infection. Recovery is faster and more stable. With Fosprenil, the animal more actively restores its weight, even if the amount of feed is not increased.

Fosprenil is able to directly affect certain types of viruses. In particular, paramyxovirus, orthomyxovirus, togavirus, herpesvirus, coronavirus and some other non-cellular forms are susceptible to it.

After the injection, the drug enters the blood vessels and spreads throughout the body. The highest concentration of active drug compounds in the blood is achieved after half an hour. The therapeutic maximum is maintained for up to 10-16 hours. During this time, the drug manages to have a therapeutic effect. Accumulation of active substances is observed in the liver, spleen, and genitals. Excretion of half-life products occurs through the kidneys with urine and through the intestines with feces.

Special instructions, storage, price

The product can be stored at a temperature of +4...+25 degrees in dark places. The medicine is transported in original packaging.

Release form:

1. The composition is available in containers of 2, 5, 10, 50, 100 ml, as well as in bottles of 0.45 and 2 liters.
2. The bottle is closed with a rubber stopper fixed with an aluminum cap.
3. Fosprenil is packaged in cardboard boxes. Instructions are included with the drug.

The period of use is 24 months from the date of release, after which the use of the medicine is prohibited.

The safety rules are identical to the instructions provided for working with all veterinary drugs. Food should be stored separately.

If the substance comes into contact with the skin , wash thoroughly.

What is Fosprenil?

The product stimulates the activity of blood plasma and also makes metabolic processes in cells more intense. The main substance here is disodium phosphate salt of polyprenols - a substance of plant origin.

The medicine is available in convenient plastic bottles and bottles with rubber stoppers; you can purchase this drug at any veterinary pharmacy. The transparent solution does not contain foreign impurities and is odorless, so animals are calm about the oral use of this medicine.

What other analogues of Fosprenil exist?

A number of immunomodulatory complexes can be used as a replacement for this drug.

There are no antiviral immunomodulators that fully correspond to Fosprenil. It is an innovative drug of a new generation.

Fosprenil dosage

The classic dosage of the drug for cats is no more than 0.2-0.3 milliliters per kilogram of animal weight. Increasing the dose is dangerous, as the cat may experience anaphylactic shock or Quincke's edema. Zoo doctors are aware of this side effect, and therefore always have medications available to stop an allergy attack. At home, it is strictly forbidden to exceed the dose!

In some cases, “Fosprenil” is not used as an injection, but is given to the animal (for example, for a cold), then the dose is doubled. The drug is given to the cat five to ten minutes before meals. Acute conditions or severe chronic forms may require the administration of 0.5 milliliters of medication for every kilogram of the cat's body weight.

Fosprenil can be used orally

It is permissible to use Fosprenil in combination with antihistamines and antibiotics. Mixing the medicine with other zoo medications is prohibited.

Negative consequences after taking Fosprenil

The manufacturer reports that during the first two days after the animal first received a dose of Fosprenil, side effects may occur. So, the cat may become drowsy, inactive, and apathetic. In addition, taking Fosprenil can cause disruptions in cardiac function, an increase or decrease in temperature.

As for contraindications, there are none as such, or rather, they have not been confirmed. The cat may suffer from individual intolerance to the main components, and an allergic reaction may also develop. Therefore, when the drug has been administered to the animal, it is better to stay in the clinic for a while in order to quickly prevent an allergy attack if it occurs.

Fosprenil has no specific contraindications

Price of "Fosprenil", analogues

“Maksidin” has a similar effect. The manufacturer of all three drugs is similar, the factories are located in Russia. The cat owner has the right to independently decide which medicine is more convenient and profitable for him to purchase, and can keep them in the pet first aid kit. Even before contacting a veterinarian, it is not forbidden to administer a prophylactic dose of the drug to the animal in order to gain time and prevent the disease from developing.

The drug costs 650-700 rubles

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The causes of death were hemorrhagic stroke, multiorgan failure in the early postoperative period after coronary artery bypass grafting. That is, nothing has been proven; this drug is recommended at the level of additional therapy. The authors of the article are compatriots, including our old friend Dr. Sultanov.

Again, in the authors we see compatriots, there is no complete information about where they made these conclusions and how, but these statements that Ropren reduces the risk of developing cirrhosis of the liver are in themselves casuistic. By what criteria is the reduction in the risk of disease development generally assessed, by what mechanism? No information available. That is, the drug claims to be of proven effectiveness and possible benefit. The main thing is to be featured in a major medical resource. Describes how protein molecules and their connections with cell membrane receptors are restored and stabilized.

The article states that it has been proven effective based on RCTs. And now the most interesting thing: according to the study, patients receive the drug Essentiale as a comparison drug. That is, in studies to prove the effectiveness of a drug, the comparison group uses a drug without proven effectiveness, which is not registered in developed countries, which is not considered a drug, which does not have a mechanism of action, and then, according to comparison with it, Ropren has been proven effective, They also found that it is more effective than the ineffective Essentiale.

Moreover, it is specified at the end that it is recommended to use Ropren in complex therapy. So it’s not that effective?! And now we look who the author is and we see the name of our friend, Doctor Sultanov, and in the list of references used, Doctor Sultanov refers to himself. In studies of the effectiveness of Ropren, the comparison drug was Piracetam, which is not approved by the FDA for sale in the United States, or even for use as a dietary supplement. Systematic reviews and meta-analyses of studies on Piracetam have not established its effectiveness.

Piracetam belongs to the fourth and last class of evidence of effectiveness - that is, based on opinions, expert assessments, and single clinical observations.

That is, in this case, studies were also conducted comparing the developed drug with an ineffective drug, then on these grounds recommendations were made to prescribe Ropren for the treatment of neurodegenerative diseases, the consequences of ischemic and traumatic brain damage. And who researches everything here and recommends polyprenols, in the end? Of course our friend Vagif Sultanov. It turns out that the drug made from polyprenols, created by Dr. Sultanov, has evidence of effectiveness only according to his own articles and studies.

The most interesting thing is that there are no other analogues of drugs made from polyprenols. On Ropren’s website there is just an explanation for this from an interview with the director of Solargan V.

It was here that the technology for extracting polyprenols of pharmaceutical grade was developed and they were studied so much that this allowed Russian scientists to create a medicine based on them - the drug Ropren.

A new class of hepatoprotectors has been created based on polyprenols. A hepatoprotector of this class allows the restoration of deeply damaged hepatocytes, showing its effectiveness even with progressive cirrhosis, as proven by clinical studies.

Dosage form

Here are some more interesting points. Dr. Vagif Sultanov, our hero, founder and developer of polyprenol medicine, founded in the year.

Moscow, Gamaleyi st. Active ingredient: 1 ml contains 4 mg of sodium polyprenyl phosphate, glycerin, ethanol, Tween, and water for injection as auxiliary components.

The Center exclusively uses pine needle processing products - Bioeffectives. Polyprenols in veterinary medicine. Here's what else is interesting. Naturally, there are a lot of publications and studies associated with these drugs that describe their effectiveness in the treatment of herpes and FIP viral peritonitis in cats. What we are talking about here is that in field studies cats that were diagnosed with FIP were treated with polyprenyl PI.

Survival times in cats diagnosed with dry FIP treated with PI showed that of 60 animals with dry FIP, 8 survived for days and 4 out of 60 survived for days. A literature search identified 59 cats with dry FIP; no cat lived more than days.

Cats treated with PI that survived for 30 days showed improvement in clinical signs. Survival times in this study were significantly longer in cats that were not treated with corticosteroids concomitantly with PI. The addition of appetite stimulants, antiemetics, antibiotics, vitamins, or special diets was not prohibited in this study, but the study protocol did not recommend the use of corticosteroids because they cause immunosuppression, but physicians were allowed to continue corticosteroid therapy at the lowest effective dose to maintain appetite and good health for those cats who were already on therapy at the time of admission to the study.

That is, there are no specifics, and what’s more, the article has a source - the developer’s website, from which there are already links to various resources. The article also conducted an RCT: cats were experimentally infected with herpes and then monitored. Varying degrees of dehydration were observed in 7 cats in the placebo group and 8 cats in the treatment group.

The difference was not statistically significant. That is, it is specifically described that there is no difference in symptoms in infected animals treated with placebo and polyprenol. It turns out that there is no evidence of effectiveness, everything is described, but in the end it is recommended to treat with this drug, since it probably helps, which is misleading.

The drug is not used for revaccination. Combination with steroid drugs reduces the therapeutic effect of Fosprenil. It is not recommended to dilute Fosprenil with saline solutions. There are no side effects or complications associated with the use of Fosprenil.

Products from animals and birds that have been treated with Fosprenil are used for food purposes without restrictions. When working with Fosprenil, you should follow the general rules of personal hygiene and safety precautions provided for when working with veterinary medicinal products. Fosprenil should be stored out of the reach of children. Moscow, st. Gamaleyi, d. Registration number PVR Alphabetical index Search by manufacturers new! Polyprenols and their derivatives are synthesized in the cell, play an important role in the glycosylation of glycoproteins and are an intermediate product in the biosynthesis of natural compounds containing long isoprene chains, such as ubiquinone and Moody D vitamin E.

Endogenous polyprenols, dolichols, their fatty acid esters and phosphorylated derivatives are integral components of biological membranes that affect many of the properties of the latter Rip J.

As preliminary studies have shown, the new drug has antiviral properties and meets many of the requirements for drugs of this class. Khaitov P.

Phosprenil does not have toxic properties; exceeding the therapeutic dose by several times did not lead to the death of animals. With long-term use, the drug does not have embryotoxic properties, carcinogenicity, does not cause allergies or addiction. However, the mechanisms of its antiviral action have not been fully identified. It is assumed that it affects the assembly or interaction of the viral particle with the receptors of the target cell, as a result of which the infection either does not develop or defective particles are formed.

Another mechanism for the antiviral action of fosprenil may be related to its ability to increase natural! V, Danilov L.

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Purpose of the work: to study the effect of fosprenil on some indicators of immunity under normal conditions and during influenza infection in experimental animals. To determine the effect of fosprenil on the production of cytokines in vivo and in vitro and to evaluate the expression of receptors for them. To study the effect of fosprenil on the activity of natural killer cells in the spleen of mice EKK in vivo and in vitro. To compare changes in the immune system caused by fosprenyl under normal conditions in intact animals and during experimental influenza infection in mice.

Scientific novelty and practical significance of the work. For the first time, it was established that fosprenil does not have a mitogenic effect on the lymphocytes of the spleen of mice, but suppresses their proliferation caused by Con A, and also reduces the expression of the receptor complex for IL. For the first time, data were obtained that the administration of fosprenil to experimental animals briefly increases the activity of NK cells in the spleens of mice, and then reduces it below the initial level one day after administration of the drug, while the decrease in NK activity is associated with an increase in cyclooxygenase activity.

It was shown for the first time that the addition of fosprenil to a culture of spleen cells reduces the production of IL-2 and IL caused by Con A, while the administration of fosprenil to experimental animals stimulates production. An experimental scheme for the prevention of influenza using fosprenil has been developed. The data obtained can be used in the development of a new preventive anti-influenza drug with direct antiviral and immunomodulatory effects.

Approbation of work. Gamaleya RAMS December 26th. Fragments of the research were reported at scientific conferences: the 5th Immunological School named after. The total volume of the dissertation is pages. The dissertation is illustrated with 21 figures and 12 tables. Influenza A virus. EMC virus. To perform immunological reactions, the spleen or thymus was taken from the animals. The organs were dissected and homogenized in a glass homogenizer. The number of cells was counted in a Goryaev chamber.

Cytotoxic activity of cells. The cytotoxic activity of NK in a suspension of mouse splenocytes was assessed using a radiometric technique modified by Rykov M. A monolayer of L cells labeled with 3H-uridine was used as target cells. The cells were added to the wells of a well plate, incubated for 24 hours, washed, effector cells were added in different dilutions, and pancreatic RNKase was added at a dose of 5.0. After the incubation period, the contents of the wells were deposited onto Whatman fiberglass filters using a Flow channel harvester, UK.

The blast transformation reaction is the lymphocyte proliferation reaction.

Living in an urban environment with an unfavorable environmental situation and a lot of stress has a negative impact on the animal's immune system. She often works under overload and needs timely support. Such support is the use of immunomodulators. In recent years, the tendency towards the introduction of medicinal products and substances of natural, including plant origin, into the domestic and foreign markets has become more and more clearly and vividly manifested. Substances synthesized in the needles of coniferous plants have a wide range of biological activities.

To stage RBTL, a suspension of lymphoid cells was prepared in a culture medium. Incubation was carried out in well plates. Thousands of cells were added to each well. Incubation time ranged from 48 to hours depending on the stimulant used.

When studying nonspecific cell proliferation under the influence of mitogens, the incubation time was hours. Incubation was carried out under standard conditions.

Proliferative activity was assessed by the inclusion of a radioactive label in the DNA of cells cultured with the drug or mitogen, relative to the control. Functional assessment of the expression of receptors for IL-1 and IL. Determination of IL production. To obtain a supernatant containing IL-1, cells were stimulated for 16 hours with the mitogen Con A. IL-1 from Calbiochem was used as a standard preparation.

Usage

Depending on the need, the use of fosprenil is divided into two types:

• For treatment;
• As a prophylactic.

It is noted that the drug is highly effective. This is especially true for diseases for which treatment was started at an early stage. The use of fosprenil at the beginning of therapy often gives the greatest result.

The drug is most effective in the fight against infectious and bacterial infections.

Fosprenil is used in the following cases:

• Rhinotracheitis;
• Plague;
• Infectious type peritonitis;
• Panleukopenia;
• Cat flu;
• Calcivirus;
• Hepatitis;
• Enteritis;
• Colitis;
• Upper respiratory tract diseases;
• Gastrointestinal diseases.

Directions for use and dose

Fosprenil has virtually no contraindications. It can be used either once or in combination with other medications. For preventive purposes, the drug is used in the form of a liquid solution. Fosprenil is administered intravenously or intramuscularly into the cat's body. There is another way. You can wipe your pet's nasal passage and eyes after contact with a sick animal to reduce the risk of infection to a minimum. It would also be a good idea to inject your cat once to achieve the same effect. 1 ml is enough for this.

If necessary, repeat the course, paying attention to changes in symptoms. When using Fosprenil for kittens, the dosage changes

It is only up to 1 ml per day. Despite the fact that the medicine is allowed to be used by children, it should not be abused.

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Personal prevention measures

According to the instructions, empty drug containers must not be used for household purposes; it must be disposed of with household waste. If the drug accidentally gets on the skin or mucous membranes, it should be washed off immediately with running water and soap. When using Fosprenil, it is necessary to follow the rules of personal hygiene and safety precautions provided for when working with medicinal products for veterinary use. At the end of the work, you should thoroughly wash your face and hands with soap and rinse your mouth with water.

People with hypersensitivity to the components of the drug should avoid direct contact with Fosprenil. All work with the drug should be carried out using special clothing and personal protective equipment (rubber gloves, goggles, respirator or protective mask). While working with the drug, do not drink, smoke or eat. If allergic reactions occur and/or if the drug accidentally enters the human body, you should immediately contact a medical facility (bring with you the instructions for use of the drug or the label).