What is Ordermil, indications for use, release forms
The medicine is an ear ointment - it has an antiparasitic, anti-inflammatory effect, relieves inflammation, destroys fungi and bacteria in the ear canal. The product also treats otodectosis, which is complicated by additional problems, including infections. The ointment has a yellow color, gel-like texture and no odor.
The goods are packaged in tubes, the finished Oridermil ointment is packed in cardboard boxes, the instructions must be included, but the administration must be carried out under the supervision of the attending physician. Depending on the size of the animal and the clinical picture, you can purchase a product with a volume of 10 or 30 grams.
Ordermil 10g, description
Compound
1 g min contains Permethrin 10 mg Neomycin sulfate 3500 ME Nystatin 100 LLC ME Triamcinolone acetonide 1 mg Excipients up to 1000 mg
Properties
The active substance of the drug neomycin Sulfate is an antibiotic of the aminoglycoside group, which has an antimicrobial effect against gram-positive and some gram-negative microorganisms: Staph, albus; Staph.aureia; E. coll; Proteus;_ Corynebacterium pyogenes; Pstudomoruu. Neomycin sulfate has a bactericidal effect. The mechanism of action is to disrupt bacterial protein synthesis, which leads to damage to the cell membrane and death of the bacterium. Nystatin, which is part of Oridermil; belongs to the group of polyene antibiotics. Depending on the concentration, it has fungistatic and fungicidal effects. The mechanism of action is to damage the cell membrane of fungi. Nystatin is active against: Candida spp., Cryptococcus spp., Histoplasma spp., Blastomyces spp., Trichophyton spp., Epidermophyton spp. Pityrosporum canis.
Triamcinolone acetonide, which is part of the drug Oridermil, is a synthetic glucocorticosteroid that has an anti-inflammatory effect, the mechanism of which is based on the inhibition of phospholipase.
Permethrin is a type 1 synthetic pyrethroid. It is an ester of an analogue of chrysaitemic acid and 3-phenoxybenzyl alcohol. Permethrin, used in veterinary medicine, is a mixture of four stereoisomers (1RTRANS, 1RCIC. 1STTRANS, ISCIC). Permethrin has a neurotoxic effect on the axons of the peripheral and central nervous system, interacting with the sodium channels of insects and ticks, which leads to their death.
Indications for use
Oridermil is an antimicrobial, antiparasitic, antifungal and anti-inflammatory drug in the form of an ointment for external use for the treatment of otitis media of various etiologies in dogs and cats.
Dosage and method of administration
Before using Oridermil, it is necessary to carry out hygienic treatment of the auricle and external auditory canal: 1 drop of the drug (the size of a pea) is injected into the ear canal, then the base of the ear is gently massaged. Oridermil: used. 1 time per day for 7 days. If necessary, the course of treatment is repeated after 7 days.
The duration of the course of therapy using OriDermil is determined by the veterinarian depending on the physiological state of the animal and the course of the disease.
With otodectosis. not complicated by a bacterial infection, Oridermil should be used once every 7 days. If necessary, repeat the course of treatment after 10-14 days.
Side effects
When used, nystagmus, locomotor ataxia, and loss of balance may rarely be observed. After stopping the use of the drug, these symptoms disappear spontaneously
Contraindications
Damage to the eardrum, hypersensitivity to the components of the drug, pregnant and active animals, cats weighing less than 1.5 kg. Oridermil is not recommended for use in combination with medications containing aminoglycoside antibiotics.
Release form
Produced packaged in aluminum tubes of 10 g or 30 g, packed in cardboard boxes
Composition of Ordermil, its medicinal properties
The composition includes such an active substance as neomycin sulfate - it eliminates all types of microbes, copes with fungi, disrupts their structure, which leads to death. Nystatin is an effective antifungal substance; it effectively fights most of their types, disrupting the functioning of harmful cells. There is also triamcinolone acetonide - a product with an anti-inflammatory effect, lindane fights parasites, and lidocaine blocks nerve impulses.
Thus, the drug has an expanded spectrum of action due to its well-thought-out medicinal composition. It not only saves you from a number of viral and fungal diseases, but also protects against parasites and has an analgesic effect.
Oridermil ointment 10g. from otitis
1070 R
Composition The drug is a pale yellow ointment, oily consistency, odorless. As active ingredients, 1 g of ointment contains: permitrin 10 mg, neomycin sulfate 3.5 mg; nystatin 100,000 IU; triamcinolone acetonide 1 mg and auxiliary components. Pharmacological action Oridermil is an antimicrobial, antiparasitic, antifungal and anti-inflammatory drug in the form of an ointment for external use. Neomycin sulfate is a compound of the aminoglycoside group that has an antimicrobial effect against gram-positive and some gram-negative microorganisms: Staph. albus; Staph. aureus; E. coli; Proteus; Corynebacterium pyogenes; Pseudomonas. Neomycin sulfate has a bactericidal effect. The mechanism of action is to disrupt bacterial protein synthesis, which leads to damage to the cell membrane and death of the bacterium. Nystatin is a compound with a polyene group. Depending on the concentration, it has fungistatic and fungicidal effects. The mechanism of action is to damage the cell membrane of fungi. Nystatin is active against: Candida spp., Cryptococcus spp., Histoplasma spp., Blastomyces spp., Trichophyton spp., Epidermophyton spp. Pityrosporum canis. Triamcinolone acetonide is a synthetic glucocorticosteroid that has an anti-inflammatory effect, the mechanism of which is based on phospholipase inhibition. Lindane is a contact-acting antiparasitic agent. Acts on the nerve ganglia of insects and ticks, causing paralysis. Active against Demodex canis; Chorioptes bovis; Sarcoptes scabies and Otodectes cynotys. Lidocaine is a compound of the amide group that has a local anesthetic effect. The mechanism of action is to block the passage of a nerve impulse by depolarizing the neuron membrane. Indications The drug is intended for the treatment of otitis of various etiologies (bacterial, fungal, parasitic origin) in dogs and cats. Recommendations for use Oridermil is used for medicinal purposes in dogs and cats with otodectosis complicated by a bacterial or fungal infection once a day for 7 days; if necessary, the course of treatment is repeated after 7 days. In the initial stage of otodectosis, the drug is used twice with an interval of 5-7 days; if necessary, the course of treatment is repeated after 7-14 days. Before using the drug, hygienic treatment of the auricle and external auditory canal is carried out. After this, 0.5 cm of ointment is injected into the ear canal and the base of the ear is gently massaged. The drug is used 1-2 times a day, with an interval of 1 day, for 6-10 days. Contraindications The drug is contraindicated for use in cases of perforation of the eardrum, hypersensitivity to the components of the drug, pregnant and lactating animals, cats weighing less than 1.5 kg. Side effects When using Oridermil, in rare cases, nystagmus, locomotor ataxia, and loss of balance may be observed. After stopping the use of the drug, these symptoms disappear spontaneously. Storage conditions The drug is stored with caution (list B) in a dry place, protected from light, inaccessible to children and animals, separately from food and feed at a temperature of 15-25 C.
Characteristics
Data
Ordermil: instructions for use, rules of use, dosage
How to use Ordermil? The instructions for use contain a comprehensive answer: the ear should be treated first - this will increase the effectiveness of the effect. Then 1 drop of the product is injected into the ear canal 2 times a day, the ear is gently massaged, and warmed up as much as possible. The procedure is carried out within a week, sometimes the period increases to 10 days. Precautionary rules should be followed: avoid contact with other animals and children, store the drug in a protected and inaccessible place, as it has a moderate degree of toxicity and danger.
Note! During the treatment period, it is worth protecting your pet by excluding contact with virus carriers; a gentle regime and strengthening the immune system are also recommended.
The medicine is an ear ointment - it has an antiparasitic, anti-inflammatory effect, relieves inflammation, destroys fungi and bacteria in the ear canal. Source: Flickr (ピットン)
Instructions for use
How to use Ordermil? The instructions for use contain complete information. First, you need to clean the ear - this way, the effectiveness of the drug increases . Afterwards, one drop of ointment is injected into the canal twice a day, and the ear is gently massaged for maximum warming. Treatment lasts for a week, but, judging by reviews, in some cases the period can be extended to 12 days. It is necessary to strictly follow all precautions: contact of the pet with other animals, as well as small children, is prohibited; the ointment must be stored in a protected place, since it has a medium level of danger.
During treatment, it is necessary to protect your pet by excluding contact with various infections; a moderate or mild regimen is also required to restore the immune system.
Side effects and contraindications
There are certain contraindications when this ointment cannot be used:
- allergic reactions and hypersensitivity to ointment substances;
- perforation of the ear drum;
- simultaneously with antibiotics;
- during pregnancy and lactation.
Side effects are quite rare, of which the following are noted:
- locomotor ataxia (a disease in the cerebellum of the brain);
- imbalance and loss of space;
- nystagmus (constant oscillatory movements of the eyes on different sides).
In most cases, as reviews say, the use occurs without side effects, no signs or pathologies occur.
Security measures:
- Upon completion of the procedure, wash your hands with warm soapy water.
- During the procedure you should not smoke, eat or drink liquids.
- If this product gets into your eyes or skin, it should be washed off immediately with running water; if it gets inside, go to the hospital.
- You should not allow your pet near children or other animals while undergoing treatment.
- Empty drug flasks cannot be used for household tasks.
Contraindications to this drug, possible adverse reactions
There are a number of contraindications when the medicine is prohibited from use:
- perforation of the eardrum;
- sensitivity to components, allergic reactions;
- during pregnancy and lactation;
- in combination with antibiotics.
Side effects are extremely rare, among them are:
- nystagmus (rhythmic oscillating movements of the eyes from side to side);
- loss of balance and orientation in space;
- locomotor ataxia (cerebellar damage).
Basically, the reception is painless, no symptoms or deviations are observed.
Oridermil
Instructions for the use of Oridermil ointment for the treatment of otodectosis in dogs and cats (developer organization: VETOKINOL S.A., Magny-Vernois 70200 Lure, France)
I. General information Trade name of the medicinal product: Oridermyl®. International nonproprietary name: permethrin, neomycin, nystatin, triamcinolone. Dosage form: ointment for auricular use.
Oridermil in 1 g contains as active ingredients: permethrin - 10 mg, neomycin sulfate - 5.145 mg, nystatin - 100,000 IU, triamcinolone acetonide - 1 mg, and as excipients: polyethylene wax and liquid paraffin - up to 1 g.
In appearance, Oridermil is a pale yellow, odorless ointment. The shelf life of the ointment, subject to storage conditions in the manufacturer's closed packaging, is 36 months from the date of production, after the first opening of the package (tube) - 28 days. It is prohibited to use Oridermil after the expiration date.
Oridermil is produced packaged in 10 g and 30 g pieces in aluminum tubes, closed with screw caps and packaged in cardboard boxes complete with 1 polyvinyl chloride cannula. Each package is supplied with instructions for using the drug. Store in sealed manufacturer's packaging, separate from food and feed, in a dry place, protected from direct sunlight, at a temperature of 15°C to 25°C, out of reach of children. Unused medicinal product is disposed of in accordance with legal requirements.
Conditions of release: without a veterinarian's prescription.
II. Pharmacological properties Oridermil refers to combined drugs for auricular (intra-auricular) use. Thanks to the combination of active components with different mechanisms of action, the drug has a wide spectrum of antimicrobial, acaricidal, antifungal activity, and has an anti-inflammatory effect.
Permethrin is a synthetic pyrethroid. The mechanism of action of permethrin is to disrupt the permeability of sodium channels in the membranes of nerve cells of insects and ticks, thereby providing an acaricidal effect. Neomycin sulfate belongs to the aminoglycoside group of antibiotics and has an antimicrobial effect against gram-positive and some gram-negative microorganisms, including: Staphylococcus spp., Proteus spp., Pseudomonas spp. Corynebacterium pyogenes, E. coli. Neomycin sulfate has a bactericidal effect, the mechanism of which is to disrupt protein synthesis in the bacterial cell, which leads to disruption of the structure of the cell membrane and death of the bacterium. Nystatin is a polyene antibiotic; depending on the concentration, it has a fungistatic and fungicidal effect, the mechanism of which is damage to the cell membrane of fungi. Active against Candida spp.. Cryptococcus spp., Histoplasma spp., Blastomyces spp.. Trichophyton spp., Fpidermophyton spp., Pityrosporum canis. Triamcinolone acetonide is a synthetic glucocorticosteroid. Suppresses the functions of leukocytes and tissue macrophages. Limits the migration of leukocytes to areas of inflammation. It disrupts the ability of macrophages to phagocytose, as well as to form interleukin-1. Helps stabilize lysosomal membranes, thereby reducing the concentration of proteolytic enzymes in the area of inflammation. Reduces capillary permeability due to the release of histamine. Suppresses the activity of phospholipase A2, which leads to suppression of the synthesis of prostaglandins and leukotrienes.
In terms of the degree of impact on the body, Oridermil is classified as a low-hazard substance (hazard class 4 according to GOST 12.1.007-76).
III. Directions for use Oridermil is prescribed for therapeutic purposes to dogs and cats with otodectosis complicated by a bacterial and/or fungal infection.
Contraindication for use is increased individual sensitivity to the components of the drug. It is forbidden to use Oridermil if the eardrum is perforated, as well as for cats weighing less than 1.5 kg.
Oridermil is used auricularly. Before using the drug, hygienic treatment of the auricle and external auditory canal is carried out. About 0.5 cm of ointment is injected into the ear canal and the base of the ear is gently massaged.
In the initial stage of otodectosis, the drug is used twice with an interval of 5-7 days. For otodectosis complicated by a bacterial and/or fungal infection, the drug is used once a day for 7 days. If necessary, the course of treatment is repeated after 7-14 days. The ointment must be administered into both ears, even if only one is affected by otodectosis.
In case of an overdose of the drug in animals, irritation of the skin in the area of the auricle and ear canal may occur.
The specific effects of the drug upon first use or upon its withdrawal have not been established. The drug is not intended for use during pregnancy and lactation. You should avoid skipping the next dose of the drug, as this may lead to a decrease in its therapeutic effectiveness. If one or more doses are missed, the course of treatment must be resumed in the prescribed dosages and dosage regimen.
As a rule, there are no side effects or complications when using Oridermil in accordance with these instructions. In rare cases, after using the drug, animals may experience skin irritation in the area of the auricle and ear canal, locomotor ataxia and tremor, which spontaneously disappear after stopping its use. In case of increased individual sensitivity of animals to the components of the drug and the appearance of allergic reactions, the use of Oridermil is stopped and desensitizing therapy is carried out.
It is prohibited to use Oridermil simultaneously with drugs containing aminoglycoside antibiotics, as well as with drugs for auricular use.
The drug is not intended for use in productive animals.
IV. Personal preventive measures When working with Ordermil, you should follow the general safety rules provided for when working with medicinal products for veterinary use. When working with the drug, general rules of personal hygiene should be observed. Empty drug packaging must not be used for household purposes; they must be disposed of with household waste. People with hypersensitivity to the components of the drug should avoid direct contact with Oridermil. In case of accidental contact of the drug with the skin or mucous membranes, rinse them immediately with plenty of water. If allergic reactions occur or if the drug accidentally enters the human body, you should immediately contact a medical facility (bring the instructions for use or label with you).
With the approval of this instruction, the instructions for use of Oridermil, approved by Rosselkhoznadzor on March 19, 2015, become invalid. Names and addresses of production sites of the manufacturer of the medicinal product for veterinary use: VETOQUINOL SA, Magny-Vernois, 70200 Lure, France.
Pros and cons of Ordermil, comparison with analogues
Despite the seeming obviousness of choosing such a product, it has a significant drawback: the high cost, reaching 500 rubles per bottle. Wealthy pet owners buy Oridermil, but analogues are much cheaper and are affordable for absolutely everyone. However, an analogue such as Surolan remains quite in demand: it is not inferior in price, but shows excellent effectiveness and an almost complete absence of contraindications.
Another popular product from the Polish manufacturer is Pananalog. Its advantage is the widest possible range of effects: it also copes with wounds and any skin lesions, but it is quite difficult to find it on sale. Aurizon ear drops are easy to use, well tolerated by animals, and are recommended by veterinarians. In general, there are quite a lot of analogues - they differ not only in price, but also in efficiency of use.
Now you know what Ordermil is, instructions for use are also given, so taking the drug and treating your animal should not cause difficulties. However, before use, you need to consult a doctor so that he can accurately diagnose and advise you on the presence of contraindications.
Reviews
Reviews and the manufacturer say that the drug is used successfully, without causing any pathologies, side effects or other symptoms. A significant disadvantage of Ordermil is its price (600 rubles for 10g); it has many analogues, and their effect and safety are not inferior. In any case, consult a veterinarian before use.
- “For a long time we couldn’t cope with the disease (ear mites) in our cat, who was constantly scratching his ears until they bled and was suffering. We took him to the veterinarian, where they recommended Ordermil - now our pet has recovered. Everyone is happy!”
- “According to all the symptoms described on the forum, the cat had otitis media. There I learned about the ointment. Although it’s not cheap, after reading the information I decided to buy it. Result – 100%"
- “I have both cats and dogs, because I can’t imagine my life without animals. I don’t know which of them brought the ear mite into the house. But they used it for a cat who had problems with her ears. The veterinarian suggested ordermil, and we were completely satisfied with its effect.”
